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[西伯利亚十个蒙古人种群体线粒体DNA V区的缺失-插入多态性,缺失频率与当地地理坐标相关]

[Deletion-insertion polymorphism in the V-region of mitochondrial DNA in ten Mongoloid populations of Siberia, Frequency of deletion correlates with the geographic coordinates of the locality].

作者信息

Petrishchev V N, Kutueva A B, Rychkov Iu G

出版信息

Genetika. 1993 Jul;29(7):1196-204.

PMID:8396544
Abstract

Deletion-insertion polymorphism in the V-region of mitochondrial DNA was analysed in ten mongoloid populations of Siberia. Frequencies of 9-bp deletion and 4-bp insertion in the populations were: 7.7 and 1.5% in Buryats; 10.2 and 0.8% in north Altais: 1.4 and 0.0% in Nanays; 1.5 and 0.0% in eastern Evenks; no deletions and insertions of such type were revealed in western Evenks, and also in Mansi, Yakuts, Chukcha and Eskimos. Correlation analysis of the data about the populations from Siberia, foreign Asia and Oceania revealed a geographical gradient of the deletion frequency which increases towards the East. The azimuth of the deletion frequency geographical gradient direction is 170 degrees. The deletion frequency gradient (Z) within the limits from the subarctic regions of Siberia to the west regions of Oceania is described quite completely with the multiple regression equation: Z = 30.516 - 0.840 (latitude) + 0.145 (longitude). The part of geographical factor within the total variability of the deletion frequency is 64%. The regularity discovered does not extend to the indian population of America.

摘要

对西伯利亚的十个蒙古人种群体的线粒体DNA V区的缺失-插入多态性进行了分析。这些群体中9碱基对缺失和4碱基对插入的频率分别为:布里亚特人7.7%和1.5%;阿尔泰北部人10.2%和0.8%;那乃人1.4%和0.0%;东部埃文克人1.5%和0.0%;在西部埃文克人以及曼西人、雅库特人、楚科奇人和爱斯基摩人中未发现此类缺失和插入。对来自西伯利亚、亚洲其他地区和大洋洲的群体数据进行的相关分析显示,缺失频率存在地理梯度,且向东增加。缺失频率地理梯度方向的方位角为170度。从西伯利亚的亚北极地区到大洋洲西部地区范围内的缺失频率梯度(Z)可用多元回归方程相当完整地描述:Z = 30.516 - 0.840(纬度)+ 0.145(经度)。地理因素在缺失频率总变异性中的占比为64%。所发现的规律并不适用于美洲的印第安人群体。

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