Willumsen B M, Ulrich K, Kieler J
Int J Cancer. 1979 Feb;23(2):209-16. doi: 10.1002/ijc.2910230212.
ST-L1 is a cell line established from lung explants from a normal ST/a mouse. The ST-L1 cells have undergone spontaneous malignant alteration in vitro. The cells were rejected after inoculation into syngeneic immunocompetent hosts, and a syngeneic humoral immuneresponse against the ST-L1 cells has been detected. The specificity of this humoral response was investigated. The syngeneic response to ST-L1 was characterized by indirect immunofluorescence tests and by immunoprecipitation of radiolabelled cells and of a C-type virus produced by the cell lines. The specific anti-ST-L1 reactivities were found to be directed against the envelope glycoprotein of an endogenous C-type virus expressed by the antigenic cell line.
ST-L1是从正常ST/a小鼠的肺外植体建立的细胞系。ST-L1细胞在体外发生了自发的恶性改变。将这些细胞接种到同基因免疫活性宿主中后被排斥，并且已检测到针对ST-L1细胞的同基因体液免疫反应。对这种体液反应的特异性进行了研究。通过间接免疫荧光试验以及对放射性标记细胞和细胞系产生的C型病毒进行免疫沉淀，对针对ST-L1的同基因反应进行了表征。发现特异性抗ST-L1反应性针对抗原性细胞系表达的内源性C型病毒的包膜糖蛋白。
