与哺乳动物C型RNA病毒相关的常见细胞表面抗原。细胞膜结合的gs抗原。
Common cell surface antigen associated with mammalian C-type RNA viruses. Cell membrane-bound gs antigen.
作者信息
Yoshiki T, Mellors R C, Hardy W D, Fleissner E
出版信息
J Exp Med. 1974 Apr 1;139(4):925-42. doi: 10.1084/jem.139.4.925.
Abstract
The indirect membrane immunofluorescence test and the absorption analysis of rabbit anti-FeLV, rabbit anti-FeLVp 30, and rabbit anti-MuLVp 30 antisera yielded the following conclusions. An antigen shared by mammalian (murine and feline) C-type RNA leukemia and sarcoma viruses was detected on the surface of cells infected or transformed by C-type viruses. The antigen was characterized as membrane-bound gs antigen bearing two determinants, membrane-bound gs-1, intraspecies-specific antigenic determinant, and membrane-bound gs-3, interspecies-specific antigenic determinant. Membrane-bound gs antigen was located on the cell surface, frequently near the site of virus budding but not on the envelope of murine C-type RNA virus.
摘要
兔抗猫白血病病毒（FeLV）、兔抗FeLV p30及兔抗鼠白血病病毒（MuLV）p30抗血清的间接膜免疫荧光试验和吸收分析得出以下结论。在受C型病毒感染或转化的细胞表面检测到一种哺乳动物（鼠类和猫科）C型RNA白血病和肉瘤病毒共有的抗原。该抗原的特征为膜结合gs抗原，带有两个决定簇，即膜结合gs-1（种内特异性抗原决定簇）和膜结合gs-3（种间特异性抗原决定簇）。膜结合gs抗原位于细胞表面，常靠近病毒出芽部位，但不在鼠C型RNA病毒的包膜上。
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