Itano S, Hirai K, Yoshida T, Kajiwara M, Ijuin H, Ban S, Sakata K, Ono N, Noguchi H, Sakai T
Second Dept. of Medicine, Kurume University School of Medicine.
Gan To Kagaku Ryoho. 1993 Aug;20(11):1512-5.
The subjects were 20 cases with implantable reservoir systems for unresectable hepatic tumors. We evaluated the correlation between a complication of the gastro-duodenum after intra-hepatic arterial chemotherapy and a gastro-duodenal distribution of anti-cancer drugs using the hepatic perfusion scintigram by 99mTc-macroaggregated albumin via reservoirs. The 20 cases were divided into 3 groups (A, B, C) according to the level of gastro-duodenal accumulation of 99mTc-MAA. In group A with the strongest accumulation in the gastro-duodenum, we frequently found a gastro-duodenal ulcer after intra-hepatic arterial chemotherapy. There was a significant difference between group A and group C, the latter without a gastro-duodenal accumulation. These results suggested that the hepatic perfusion scintigram via reservoir was a useful examination to expect and prevent the complication of gastro-duodenum on intra-hepatic arterial infusion (especially continuous infusion) chemotherapy.
研究对象为20例患有不可切除性肝肿瘤且植入了储液器系统的患者。我们通过储液器使用99mTc-大颗粒聚合白蛋白肝灌注闪烁显像，评估肝内动脉化疗后胃十二指肠并发症与抗癌药物在胃十二指肠分布之间的相关性。根据99mTc-MAA在胃十二指肠的积聚程度，将20例患者分为3组（A组、B组、C组）。在胃十二指肠积聚最强的A组中，我们在肝内动脉化疗后经常发现胃十二指肠溃疡。A组和C组之间存在显著差异，C组无胃十二指肠积聚。这些结果表明，通过储液器进行肝灌注闪烁显像对于预测和预防肝内动脉灌注（尤其是持续灌注）化疗时胃十二指肠的并发症是一种有用的检查方法。
