Tricoire J, Claeyssens-Donadel S, Robert A, Rolland M, Moulin F, Kulhein E, Berrebi A, Izopet J, Puel J
Service de médecine infantile B, CHU Purpan, Toulouse.
Pediatrie. 1993;48(4):283-6.
Early predictive factors of HIV infection in infants born to HIV infected mothers were carried out to evaluate the roles of immunological parameters for the diagnosis and prognosis of HIV infection. T-lymphocyte subsets and serum immunoglobulins were studied on cord blood in three groups of neonates: 14 infected infants, 29 sero-reverted infants and 31 control neonates. No differences were observed between the three groups. At 3 months, IgG were significantly higher in the infected infants than in sero-reverted infants. After 6 months, CD4 + cell counts, CD4/CD8 ratio were significantly lower in the infected infants and serum IgG, IgA and IgM were significantly higher in the infected group. Antigenemia p24 was detected in 78% of the infected group before 6 months. Total HIV-specific antibody persisted and progressed after 6 months. These data and viral detection appear to be complementary and useful for therapeutic strategies.
对感染艾滋病毒母亲所生婴儿的早期艾滋病毒感染预测因素进行了研究，以评估免疫参数在艾滋病毒感染诊断和预后中的作用。对三组新生儿的脐带血进行了T淋巴细胞亚群和血清免疫球蛋白研究：14名感染婴儿、29名血清学转阴婴儿和31名对照新生儿。三组之间未观察到差异。在3个月时，感染婴儿的IgG显著高于血清学转阴婴儿。6个月后，感染婴儿的CD4 +细胞计数、CD4/CD8比值显著降低，感染组的血清IgG、IgA和IgM显著升高。6个月前，感染组中78%检测到p24抗原血症。6个月后，总艾滋病毒特异性抗体持续存在并升高。这些数据和病毒检测似乎具有互补性，对治疗策略有用。
