Zalatnai A, Lapis K, Fehér I
I. Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary.
Pathol Res Pract. 1993 Jun;189(5):536-41. doi: 10.1016/S0344-0338(11)80362-6.
The alterations of the argyrophil nucleolar organizer regions (AgNORs) have been studied in hyperplastic and neoplastic human liver lesions. The material studied included: 11 focal nodular hyperplasias (FNH), 3 adenomas, 19 hepatocellular carcinomas (HCC), 2 hepatoblastomas, 8 liver metastases. In 5 cases tumor-free (normal) liver was also available for study. The mean AgNOR numbers were significantly increased in all of these lesions (in FNHs 3.36 +/- 1.43, in the adenomas 2.48 +/- 1.29, in the HCCs 3.32 +/- 1.43, in the hepatoblastomas 3.33 +/- 1.33 and in the metastases 4.86 +/- 1.54) compared to those observed in normal liver (0.86 +/- 0.85). The highly increased AgNOR number in FNHs was particularly surprising and it seemed to us that based on AgNOR numbers the FNHs could be divided into two groups. With the exception of hepatoblastomas in all primary liver lesions the AgNOR counts distributed on a rather broad scale resulting in overlapping in hyperplastic and tumourous cases. The authors concluded that the AgNOR counts reflect only the proliferative activity of a given cell population and at least in the liver they cannot serve as basis for distinction between the hyperplastic, benign and malignant neoplastic lesions.
对人类肝脏增生性和肿瘤性病变中的嗜银核仁组织区（AgNORs）改变进行了研究。所研究的材料包括：11例局灶性结节性增生（FNH）、3例腺瘤、19例肝细胞癌（HCC）、2例肝母细胞瘤、8例肝转移瘤。另外还有5例无肿瘤（正常）肝脏可供研究。与正常肝脏（0.86±0.85）相比，所有这些病变中的平均AgNOR数量均显著增加（FNH中为3.36±1.43，腺瘤中为2.48±1.29，HCC中为3.32±1.43，肝母细胞瘤中为3.33±1.33，转移瘤中为4.86±1.54）。FNH中AgNOR数量的高度增加尤其令人惊讶，在我们看来，基于AgNOR数量，FNH可分为两组。除肝母细胞瘤外，在所有原发性肝脏病变中，AgNOR计数分布范围相当广泛，导致增生性和肿瘤性病例出现重叠。作者得出结论，AgNOR计数仅反映特定细胞群体的增殖活性，至少在肝脏中，它们不能作为区分增生性、良性和恶性肿瘤性病变的依据。
