Anselmi L, Sementa A R, Borgiani L, Banderali A, Rovida S
Servizio di anatomia patologica, Ospedali Galliera di Genova.
Pathologica. 1990 Nov-Dec;82(1082):653-62.
By means of a silver staining method, Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of 58 ultrasound-guided liver biopsy specimens. These included 12 normal livers, 12 cirrhotic livers, 12 cases of chronic hepatitis and 22 cases of hepatocellular carcinoma. A significant difference (P less than 0.001) was found between the mean AgNOR scores of the normal and pathological biopsies, and between the non-neoplastic and the carcinomatous lesions. The authors suggest that AgNOR counts, in combination with conventional histocytological criteria, may be a useful method in the diagnosis of liver diseases.
通过银染色法，对58例超声引导下肝活检标本石蜡切片中的核仁组织区相关蛋白（NORs）进行了评估。这些标本包括12例正常肝脏、12例肝硬化肝脏、12例慢性肝炎以及22例肝细胞癌。正常活检组织与病理活检组织的平均AgNOR评分之间，以及非肿瘤性病变与癌性病变之间存在显著差异（P＜0.001）。作者认为，AgNOR计数结合传统组织细胞学标准，可能是诊断肝脏疾病的一种有用方法。
