Babu M, Bai R P, Suguna L, Ramachandran K, Ramakrishnan K M
Biochemistry Department, Central Leather Research Institute, Madras, India.
Physiol Chem Phys Med NMR. 1993;25(2):113-20.
Spin lattice relaxation times of water protons have been reported to correlate with the water contents of malignant as well as benign tissues. In order to investigate whether such a correlation exists in keloid and hypertrophic scars, T1 values of keloid and hypertrophic scars were measured using Magnetic Resonance Imaging and compared with that of normal skin. A linear correlation of the T1 values of the scars with their age was observed. Even though both the scars exhibited higher T1 values in the early stages of lesion, a faster return to the steady state level was observed in hypertrophic scars compared to keloids. It is suggested that the measurement of T1 values could serve to differentiate the two abnormal wound healing situations.
据报道，水质子的自旋晶格弛豫时间与恶性和良性组织的含水量相关。为了研究瘢痕疙瘩和增生性瘢痕中是否存在这种相关性，使用磁共振成像测量了瘢痕疙瘩和增生性瘢痕的T1值，并与正常皮肤的T1值进行比较。观察到瘢痕的T1值与其年龄呈线性相关。尽管两种瘢痕在病变早期均表现出较高的T1值，但与瘢痕疙瘩相比，增生性瘢痕更快恢复到稳态水平。提示测量T1值有助于区分这两种异常伤口愈合情况。
