Maisin J R, Albert C, Henry A
Université Catholique de Louvain, Unité de Radiobiologie et de Radioprotection, Brussels, Belgium.
Radiat Res. 1993 Sep;135(3):332-7.
The advantages gained by a combined treatment of different chemical protectors on short-term lethality of X-irradiated adult male mice have been studied. The following compounds were given alone or in a mixture of two or three compounds: 16,16-dimethyl PGE2 (PGE2), cysteine (Cys), glucan, glutathione (GSH), 5-hydroxytryptamine (5-HT), mercaptoproprionylglycine (MPG), or WR-2721. The survival of mice treated before X irradiation with the optimal dose of each radioprotector given separately shows that WR-2721 and 5-HT yield the best protection with dose reduction factors (DRFs) of 2.2 and 1.7, respectively. Cysteine, glucan, PGE2, MPG, and GSH, with DRFs of 1.4, 1.4, 1.2, 1.1, and 1.1, respectively, are less efficient radioprotectors. When PGE2 was combined with a low dose of WR-2721 (200 mg/kg), the protection increased in a synergistic way. The increase in protection offered by a combination of PGE2 with Cys, glucan, GSH, or 5-HT is less marked and the effect obtained is only additive. A synergistic action is also obtained with a combination of WR-2721 (200 mg/kg) and 5-HT (8 mg/kg) (DRF 2.7).
研究了不同化学防护剂联合处理对X射线照射成年雄性小鼠短期致死率的影响。以下化合物单独或两种或三种混合使用：16,16 - 二甲基前列腺素E2（PGE2）、半胱氨酸（Cys）、葡聚糖、谷胱甘肽（GSH）、5 - 羟色胺（5 - HT）、巯基丙酰甘氨酸（MPG）或WR - 2721。在X射线照射前分别给予每种辐射防护剂最佳剂量处理的小鼠存活率表明，WR - 2721和5 - HT的防护效果最佳，剂量降低因子（DRF）分别为2.2和1.7。半胱氨酸、葡聚糖、PGE2、MPG和GSH的DRF分别为1.4、1.4、1.2、1.1和1.1，是效果较差的辐射防护剂。当PGE2与低剂量的WR - 2721（200 mg/kg）联合使用时，防护作用以协同方式增强。PGE2与半胱氨酸、葡聚糖、GSH或5 - HT联合使用时防护作用的增强不太明显，得到的效果只是相加性的。WR - 2721（200 mg/kg）和5 - HT（8 mg/kg）联合使用也获得了协同作用（DRF为2.7）。
