Engel P, Cummings J L, Villanueva-Meyer J, Mena I
Department of Medicine, University of Connecticut School of Medicine, Farmington.
J Geriatr Psychiatry Neurol. 1993 Jul-Sep;6(3):144-51. doi: 10.1177/089198879300600303.
Sixteen patients with dementia (nine with Alzheimer's disease and seven with multi-infarct dementia) were studied with xenon-133 and hexamethyl-propyleneamine-oxime single photon emission computed tomography (SPECT). Quantification of cerebral blood flow was determined in 16 hemispheric regions of interest. Neuropsychological deficits were assessed with the Mini-Mental State Examination and the Neurobehavior Cognitive Status Examination. Alzheimer's disease patients had symmetric reduction of parietal lobe perfusion; multi-infarct dementia patients had multifocal perfusion deficits. Correlations were demonstrated between cerebral blood flow in the posterior brain regions and performance on tests of language, memory, attention, figure copying, judgment, and similarities. Alzheimer's disease patients exhibited more language impairment than multi-infarct dementia patients. SPECT promises to provide diagnostic information and data relevant to interpretation of neuropsychological deficits.
对16名痴呆患者（9名阿尔茨海默病患者和7名多发梗死性痴呆患者）进行了氙-133和六甲基丙烯胺肟单光子发射计算机断层扫描（SPECT）研究。在16个感兴趣的半球区域测定脑血流量。采用简易精神状态检查表和神经行为认知状态检查表评估神经心理学缺陷。阿尔茨海默病患者顶叶灌注呈对称性减少；多发梗死性痴呆患者有多处灌注缺陷。后脑区域的脑血流量与语言、记忆、注意力、图形临摹、判断力和相似性测试的表现之间存在相关性。阿尔茨海默病患者比多发梗死性痴呆患者表现出更多的语言障碍。SPECT有望提供与神经心理学缺陷解释相关的诊断信息和数据。
