Hanyu Haruo, Shimizu Soichiro, Hirao Kentaro, Kanetaka Hidekazu, Sakurai Hirofumi, Iwamoto Toshihiko, Koizumi Kiyoshi, Abe Kimihiko
Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
J Neurol Sci. 2006 Dec 1;250(1-2):97-102. doi: 10.1016/j.jns.2006.07.007. Epub 2006 Sep 26.
To determine whether combined studies of Mini-Mental State Examination (MMSE) and brain single photon emission CT (SPECT) would provide more useful means of differentiating between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), we studied 36 patients with probable DLB and 96 patients with probable AD. DLB patients had significantly better performance on word recall, but more impaired attention and copying than AD patients. We confirmed that a weighted score derived by Ala et al. [Ala, T.A., Hughes, L.F., Kyrouac, G.A., Ghobrial, M.W., Elble, R.J. The Mini-Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer' disease. Int J Geriatr Psychiatry 2002;17:503-9]: (Attention-5/3.Memory+5.Construction), was helpful in discriminating between DLB and AD. SPECT study revealed that medial occipital perfusion significantly decreased in DLB patients than AD patients. Combined studies of MMSE and brain SPECT achieved a high discrimination between DLB and AD with a sensitivity of 81% and a specificity of 85%, suggesting that there is a useful and practical approach to differentiate DLB from AD. Our findings will need to be substantiated in an independent and prospective study sample.
为了确定简易精神状态检查表（MMSE）与脑单光子发射计算机断层扫描（SPECT）的联合研究是否能提供更有效的方法来区分路易体痴呆（DLB）和阿尔茨海默病（AD），我们研究了36例可能患有DLB的患者和96例可能患有AD的患者。DLB患者在单词回忆方面表现明显更好，但与AD患者相比，注意力和临摹能力受损更严重。我们证实，Ala等人得出的加权分数（注意力-5/3×记忆力+5×结构）有助于区分DLB和AD。SPECT研究显示，DLB患者枕叶内侧灌注较AD患者显著降低。MMSE与脑SPECT的联合研究对DLB和AD具有较高的区分度，敏感性为81%，特异性为85%，这表明存在一种区分DLB和AD的有用且实用的方法。我们的研究结果需要在独立的前瞻性研究样本中得到证实。
