Yarchoan R, Mitsuya H, Broder S
Medicine branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Immunol Today. 1993 Jun;14(6):303-9. doi: 10.1016/0167-5699(93)90050-U.
Drugs that inhibit HIV replication have been shown to have clinical utility in patients with HIV infection. However, the immunological improvement induced by available anti-HIV therapies in patients with AIDS is incomplete and transient. Explanations for this may include immunological barriers to complete reconstitution, low therapeutic indices of the available drugs, and the development of viral resistance. An understanding of these processes may provide important leads for the development of improved therapy for AIDS.
已证明抑制HIV复制的药物对HIV感染患者具有临床效用。然而，现有抗HIV疗法在艾滋病患者中诱导的免疫改善并不完全且是短暂的。对此的解释可能包括完全重建免疫的免疫障碍、现有药物的低治疗指数以及病毒耐药性的产生。对这些过程的理解可能为开发改进的艾滋病治疗方法提供重要线索。
