Casanova J L, Maryanski J L
INSERM 132, Hôpital Necker-Enfants Malades, Paris, France.
Immunol Today. 1993 Aug;14(8):391-4. doi: 10.1016/0167-5699(93)90140-G.
Recent studies indicate that the T-cell receptor (TCR) repertoire selected by certain antigenic peptide-MHC combinations can be extremely diverse. This is in contrast to earlier studies reporting T-cell responses which were limited in terms of TCR diversity. In this viewpoint, we suggest these variations in TCR diversity may be explained by taking into account the homology between some antigens and self proteins to which T cells are tolerant.
最近的研究表明，由某些抗原肽-MHC组合选择的T细胞受体（TCR）库可能极其多样。这与早期报道的T细胞反应形成对比，早期研究中的TCR多样性有限。在本文观点中，我们认为TCR多样性的这些差异可以通过考虑某些抗原与T细胞耐受的自身蛋白之间的同源性来解释。
