Park J S, Namkoong S E, Lee J M, Kim E J, Chee Y H, Han G T, Kim S J
Department of Obstetrics and Gynecology, Catholic University Medical College, Seoul, Korea.
J Korean Med Sci. 1993 Apr;8(2):162-5. doi: 10.3346/jkms.1993.8.2.162.
Recently, detection of human papillomavirus (HPV)mRNA expression was made possible by in situ hybridization. We described a patient with cervical intraepithelial neoplasia (CIN) 3, showing a distinctive and rare form of co-infection with HPV type 16 and 18. HPV-16 was detected in high grade squamous intraepithelial neoplastic lesion (CIN 3) and HPV-18 was in low grade lesion just adjacent to the HPV-16 infected area. This case suggests that HPV infection may be one of the most responsible causative agents producing malignant transformation and two distinctive HPV types can also simultaneously infect the squamous epithelium of the uterine cervix.
最近，通过原位杂交技术能够检测人乳头瘤病毒（HPV）mRNA的表达。我们描述了一名患有宫颈上皮内瘤变3级（CIN 3）的患者，其显示出一种独特且罕见的HPV 16型和18型共同感染形式。在高级别鳞状上皮内瘤变病变（CIN 3）中检测到HPV - 16，而HPV - 18则存在于紧邻HPV - 16感染区域的低级别病变中。该病例表明，HPV感染可能是导致恶性转化的最主要致病因素之一，并且两种不同的HPV类型也可同时感染子宫颈鳞状上皮。
