• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

对氯苯胺基磷酸和环磷酰胺(癌得星)对磷酸酰胺酶的光镜和电镜组织化学研究

Light and electron histochemistry of phosphoamidase with p-chloranilidophosphonic acid and with cyclophosphamide (endoxan).

作者信息

Grillo T A, Baxter-Grillo D L, Abegunde J O

出版信息

Histochemistry. 1978 Dec 28;59(1):73-4. doi: 10.1007/BF00506479.

DOI:10.1007/BF00506479
PMID:83980
Abstract

The original metal-salt technique of Gomori (1948a) employing p-chloranilidophosphonic acid as a substrate for the demonstration of the activity of phosphoamidase has been used with varying success by a number of investigators for light microscopy. Cyclophosphamide (endoxan) which is a cytotoxic drug known to activate phosphoamidase and other lysosomal enzymes in neoplasm (Grillo, 1971) is proposed as another substrate for the enzyme for both light and electron microscopy.

摘要

戈莫里(1948年a)最初的金属盐技术采用对氯苯胺基膦酸作为底物来证明磷酸酰胺酶的活性,许多研究人员在光学显微镜检查中使用该技术时取得了不同程度的成功。环磷酰胺(癌得星)是一种已知能激活肿瘤中磷酸酰胺酶和其他溶酶体酶的细胞毒性药物(格里洛,1971年),它被提议作为该酶在光学显微镜和电子显微镜检查中的另一种底物。

相似文献

1
Light and electron histochemistry of phosphoamidase with p-chloranilidophosphonic acid and with cyclophosphamide (endoxan).对氯苯胺基磷酸和环磷酰胺(癌得星)对磷酸酰胺酶的光镜和电镜组织化学研究
Histochemistry. 1978 Dec 28;59(1):73-4. doi: 10.1007/BF00506479.
2
Cytochemical (icroscopic and quantitative) studies on cultured cells and biopsies of Burkitt's lymphoma. (Including a study of the effect of endoxanon lysosomal enzymes).
Afr J Med Sci. 1971 Jan;2(1):9-35.
3
[CYTOLOGICAL CHANGES IN ASCITIC AND PLEURAL PUNCTATES IN ADVANCED GYNECOLOGICAL CANCER FOLLOWING CYTOSTATIC THERAPY WITH ENDOXAN AND MEBRYL].[使用环磷酰胺和美法仑进行细胞抑制治疗后晚期妇科癌症患者腹水和胸腔穿刺液中的细胞学变化]
Cesk Gynekol. 1964 Feb;29:79-82.
4
The effect of endoxan, hydrocortisone and antistine on cell metabolism in tissue culture in vitro.癌得星、氢化可的松和安他唑啉对体外组织培养中细胞代谢的影响。
Pol Med J. 1967;6(2):471-8.
5
Electron microscopic demonstration of adenosine triphosphate phosphohydrolase activity in herring gull salt glands.银鸥盐腺中三磷酸腺苷磷酸水解酶活性的电子显微镜显示
J Histochem Cytochem. 1969 Sep;17(9):570-84. doi: 10.1177/17.9.570.
6
Phasecontrast microscopy of the Gomori reaction for alkaline phosphatase.碱性磷酸酶的Gomori反应的相差显微镜检查。
Nature. 1954 May 15;173(4411):951-2. doi: 10.1038/173951a0.
7
Effects of endoxan on oxidative processes in model systems in vitro.环磷酰胺对体外模型系统中氧化过程的影响。
Med Pregl. 2007;60 Suppl 2:121-3.
8
Action of organophosphorus compounds on cell organelles. I. Effect of tetraethyl dithio pyrophosphate on lysosomal hydrolases.有机磷化合物对细胞器的作用。I. 焦磷酸四乙酯对溶酶体水解酶的影响。
Biochem Pharmacol. 1973 Jan 15;22(2):185-94. doi: 10.1016/0006-2952(73)90272-4.
9
[Evaluation of ovarian function phases in the endometrium with the aid of histochemical reactions. Acid and alkaline phosphatase, phosphoamidase and glycogen staining].[借助组织化学反应评估子宫内膜中的卵巢功能阶段。酸性和碱性磷酸酶、磷酸酰胺酶及糖原染色]
Schweiz Med Wochenschr. 1959 Apr 18;89:433-9.
10
Demonstration of lysosomal and extralysosomal sites for acid phosphatase in mouse kidney tubule cells with p-nitrophenylphosphate lead-salt technique.用对硝基苯磷酸铅盐技术显示小鼠肾小管细胞中酸性磷酸酶的溶酶体和非溶酶体部位。
J Histochem Cytochem. 1975 Jun;23(6):439-51. doi: 10.1177/23.6.239053.

本文引用的文献

1
Histochemical demonstration of sites of phosphamidase activity.
Proc Soc Exp Biol Med. 1948 Dec;69(3):407-9. doi: 10.3181/00379727-69-16735.
2
Further studies on the histochemical specificity of phosphatases.磷酸酶组织化学特异性的进一步研究。
Proc Soc Exp Biol Med. 1949 Nov;72(2):449, illust. doi: 10.3181/00379727-72-17464.
3
The localization of acid phosphatase in rat liver cells as revealed by combined cytochemical staining and electron microscopy.通过细胞化学染色和电子显微镜联合技术揭示大鼠肝细胞中酸性磷酸酶的定位。
J Biophys Biochem Cytol. 1961 Oct;11(1):47-66. doi: 10.1083/jcb.11.1.47.
4
Histochemical demonstration of acid phosphatases with naphthol AS-phosphates.用萘酚AS-磷酸盐进行酸性磷酸酶的组织化学显示。
J Natl Cancer Inst. 1958 Sep;21(3):523-39.
5
A modification of Gomori's method for demonstration of phosphamidase in tissue sections.一种用于在组织切片中显示磷酸酶的改良Gomori方法。
J Histochem Cytochem. 1955 Mar;3(2):134-40. doi: 10.1177/3.2.134.
6
Cytochemical (icroscopic and quantitative) studies on cultured cells and biopsies of Burkitt's lymphoma. (Including a study of the effect of endoxanon lysosomal enzymes).
Afr J Med Sci. 1971 Jan;2(1):9-35.