Steenbergh P H, Jansen E, van Schaik F M, Sussenbach J S
Laboratory for Physiological Chemistry, University of Utrecht, The Netherlands.
Mol Reprod Dev. 1993 Aug;35(4):365-7. doi: 10.1002/mrd.1080350408.
The two putative promoter regions of the human insulin-like growth factor-I (IGF-I) gene, located upstream of the two alternatively used leader exons 1 and 2, were tested for promoter activity in transient transfection assays. Both regions were shown to possess promoter activity. The results further indicate cell-type-specific regulation of the activities of the two promoters in endogenously IGF-I producing human cell lines of different origin.
人胰岛素样生长因子-I（IGF-I）基因的两个推定启动子区域，位于两个交替使用的前导外显子1和2的上游，在瞬时转染试验中检测其启动子活性。结果表明这两个区域均具有启动子活性。研究结果进一步表明，在不同来源的内源性产生IGF-I的人类细胞系中，这两个启动子的活性受到细胞类型特异性调控。
