Molteni K H, George J, Messersmith R, Puppala B L, Mangurten H H, Kallen R J
Department of Pediatrics, Medical College of Wisconsin, Milwaukee.
Pediatr Nephrol. 1993 Aug;7(4):413-5. doi: 10.1007/BF00857554.
A term infant with aortic and renal artery thrombosis is described, in whom the right kidney experienced complete ischemia for 5 days. A continuous intrathrombic urokinase infusion induced complete clot lysis and reperfusion of the right kidney. Follow-up studies of renal function and renal growth have been normal. This is the first report to describe complete pharmacological salvage of a neonatal kidney after prolonged warm ischemia. This case underscores both the ability of the neonatal kidney to recover from prolonged ischemia and the need to effect thrombolysis before irreversible renal injury occurs. The intrathrombic use of fibrinolytic agents in similarly affected infants warrants consideration and further study.
本文描述了一名患有主动脉和肾动脉血栓形成的足月儿，其右肾经历了5天的完全缺血。持续的血栓内尿激酶输注导致右肾血栓完全溶解和再灌注。肾功能和肾脏生长的随访研究结果正常。这是第一份描述长时间热缺血后新生儿肾脏完全通过药物挽救的报告。该病例强调了新生儿肾脏从长时间缺血中恢复的能力，以及在不可逆性肾损伤发生之前进行溶栓的必要性。对于类似受影响的婴儿，在血栓内使用纤溶药物值得考虑并进一步研究。
