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用抗代谢物处理两种小鼠肿瘤和小肠隐窝后的溴脱氧尿苷标记的细胞凋亡。

Bromodeoxyuridine-labelled apoptosis after treatment with antimetabolites in two murine tumours and in small intestinal crypts.

作者信息

Sarraf C E, Ansari T W, Conway P, Notay M, Hill S, Alison M R

机构信息

Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

出版信息

Br J Cancer. 1993 Oct;68(4):678-80. doi: 10.1038/bjc.1993.408.

DOI:10.1038/bjc.1993.408
PMID:8398692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1968621/
Abstract

Antimetabolites are S-phase specific anticancer drugs. Administration of bromodeoxyuridine (BrdUrd) to tumour bearing mice was followed by treatment with cytosine arabinoside or hydroxyurea. Anti-BrdUrd immunocytochemistry visualised susceptible tumour and intestinal crypt cells at electron microscope level, showing unequivocally that cells that were in S-phase at the time of administration of the drugs subsequently died by apoptosis.

摘要

抗代谢物是S期特异性抗癌药物。给荷瘤小鼠注射溴脱氧尿苷（BrdUrd）后，再用阿糖胞苷或羟基脲进行治疗。抗BrdUrd免疫细胞化学在电子显微镜水平上显示了敏感的肿瘤细胞和肠隐窝细胞，明确表明在给药时处于S期的细胞随后通过凋亡死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf74/1968621/c816ea130c52/brjcancer00200-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf74/1968621/f7d9207f2997/brjcancer00200-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf74/1968621/c816ea130c52/brjcancer00200-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf74/1968621/f7d9207f2997/brjcancer00200-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf74/1968621/c816ea130c52/brjcancer00200-0035-b.jpg

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A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.
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Do cells of continually renewing populations and those stimulated from quiescence respond similarly to HU and Ara-C?持续更新群体的细胞和那些从静止状态被刺激的细胞对羟基脲（HU）和阿糖胞苷（Ara-C）的反应相似吗？
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Kinetic studies on a murine sarcoma and an analysis of apoptosis.小鼠肉瘤的动力学研究及细胞凋亡分析
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Apoptosis: a gene-directed programme of cell death.细胞凋亡：一种由基因指导的细胞死亡程序。
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