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pH对SR4233在HT - 29细胞中的需氧和缺氧细胞毒性的影响。

The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.

作者信息

Skarsgard L D, Skwarchuk M W, Vinczan A, Chaplin D J

机构信息

Department of Medical Biophysics, BC Cancer Research Centre, Vancouver, Canada.

出版信息

Br J Cancer. 1993 Oct;68(4):681-3. doi: 10.1038/bjc.1993.409.

DOI:10.1038/bjc.1993.409
PMID:8398693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1968590/
Abstract

We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tissue toxicity of this new agent.

摘要

我们已经观察到，低pH值可显著增强生物还原药物SR4233对有氧条件下的HT-29人肿瘤细胞的细胞毒性作用。在缺氧条件下未观察到这种增强作用。这种pH值效应可能与这种新药物的治疗效果和正常组织毒性都相关。

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本文引用的文献

1
Intermittent blood flow in a murine tumor: radiobiological effects.小鼠肿瘤中的间歇性血流：放射生物学效应。
Cancer Res. 1987 Jan 15;47(2):597-601.
2
Acute hypoxia in tumors: implications for modifiers of radiation effects.肿瘤中的急性缺氧：对辐射效应修饰剂的影响
Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1279-82. doi: 10.1016/0360-3016(86)90153-7.
3
SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells.SR - 4233：一种对缺氧哺乳动物细胞具有高选择性毒性的新型生物还原剂。
Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1239-42. doi: 10.1016/0360-3016(86)90267-1.
4
Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity.
Cancer Res. 1988 Nov 1;48(21):5947-52.
5
Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233).
Biochem Pharmacol. 1988 Apr 15;37(8):1487-95. doi: 10.1016/0006-2952(88)90010-x.
6
Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma.生物还原细胞毒性药物SR 4233增强黄酮乙酸对小鼠癌的抗肿瘤作用
Cancer Res. 1989 Oct 15;49(20):5664-70.
7
Pre- and post-irradiation radiosensitization by SR 4233.SR 4233对辐射前后的放射增敏作用。
Int J Radiat Oncol Biol Phys. 1989 Apr;16(4):967-71. doi: 10.1016/0360-3016(89)90897-3.
8
Interaction of SR-4233 with hyperthermia and radiation in the FSaIIC murine fibrosarcoma tumor system in vitro and in vivo.SR-4233在体外和体内FsaIIC小鼠纤维肉瘤肿瘤系统中与热疗和放疗的相互作用。
Cancer Res. 1990 Aug 15;50(16):5055-9.
9
DNA damaging effects and voltammetric studies on the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide, SR4233, as a function of pH.
Biochem Pharmacol. 1990 Sep 15;40(6):1405-10. doi: 10.1016/0006-2952(90)90410-m.
10
Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation.肿瘤缺氧可被利用来使肿瘤对分次照射优先产生敏感性。
Int J Radiat Oncol Biol Phys. 1991 Mar;20(3):457-61. doi: 10.1016/0360-3016(91)90057-b.