pH对SR4233在HT - 29细胞中的需氧和缺氧细胞毒性的影响。
The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
作者信息
Skarsgard L D, Skwarchuk M W, Vinczan A, Chaplin D J
机构信息
Department of Medical Biophysics, BC Cancer Research Centre, Vancouver, Canada.
出版信息
Br J Cancer. 1993 Oct;68(4):681-3. doi: 10.1038/bjc.1993.409.
Abstract
We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tissue toxicity of this new agent.
摘要
我们已经观察到，低pH值可显著增强生物还原药物SR4233对有氧条件下的HT-29人肿瘤细胞的细胞毒性作用。在缺氧条件下未观察到这种增强作用。这种pH值效应可能与这种新药物的治疗效果和正常组织毒性都相关。
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