Scarone S, Abbruzzese M, Gambini O
Department of Biomedical and Technological Sciences, University of Milan Medical School, Italy.
Schizophr Res. 1993 Aug;10(2):103-7. doi: 10.1016/0920-9964(93)90044-j.
The following report is an evaluation of the performances of 35 schizophrenic patients and 35 of their siblings on the Wisconsin Card Sorting Test (WCST), a neuropsychological test considered sensitive to frontal lobe functioning. Thirty five normal subjects matched for age and education were the comparison group. The purpose of this study was to examine the relationship of the neurofunctional basis for schizophrenia to its familiar occurrence. Non-schizophrenic siblings of schizophrenic patients did not perform significantly different from normal subjects on the WCST; however, schizophrenic patients performed significantly worse than both their siblings and normal subjects. These results indicate that WCST dysfunction seems to be a characteristic related to the presence of the disease and that non-genetic factors could contribute to the WCST pathological profile.
以下报告是对35名精神分裂症患者及其35名亲属在威斯康星卡片分类测验（WCST）中的表现进行的评估，该测验是一种对额叶功能敏感的神经心理学测试。选取了35名年龄和教育程度匹配的正常受试者作为对照组。本研究的目的是检验精神分裂症的神经功能基础与其家族发病情况之间的关系。精神分裂症患者的非精神分裂症亲属在WCST上的表现与正常受试者没有显著差异；然而，精神分裂症患者的表现明显比其亲属和正常受试者差。这些结果表明，WCST功能障碍似乎是与该疾病存在相关的一个特征，并且非遗传因素可能导致WCST的病理特征。
