Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.
J Clin Exp Neuropsychol. 2011 Apr;33(4):385-94. doi: 10.1080/13803395.2010.524148.
This study is one of very few that has investigated the neuropsychological functioning of both familial and clinical high risk subjects for psychosis. Participants (N = 164) were members of the Northern Finland 1986 Birth Cohort in the following four groups: familial risk for psychosis (n = 62), clinical risk for psychosis (n = 20), psychosis (n = 13), and control subjects (n = 69). The neurocognitive performance of these groups was compared across 19 cognitive variables. The two risk groups did not differ significantly from controls, but differed from the psychosis group in fine motor function. Neuropsychological impairments were not evident in a non-help-seeking high-risk sample.
这项研究是少数几项调查精神病家族和临床高危人群神经心理功能的研究之一。参与者(N=164)属于以下四个组的芬兰北部 1986 年出生队列:精神病家族风险(n=62)、精神病临床风险(n=20)、精神病(n=13)和对照组(n=69)。这些组的神经认知表现通过 19 个认知变量进行了比较。这两个风险组与对照组没有显著差异,但在精细运动功能方面与精神病组存在差异。在一个非求助的高风险样本中,并未出现明显的神经心理障碍。