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精神分裂症的不同脆弱性指标及其在芬兰北部 1986 年出生队列中的神经心理学特征。

Different vulnerability indicators for psychosis and their neuropsychological characteristics in the Northern Finland 1986 Birth Cohort.

机构信息

Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.

出版信息

J Clin Exp Neuropsychol. 2011 Apr;33(4):385-94. doi: 10.1080/13803395.2010.524148.

DOI:10.1080/13803395.2010.524148
PMID:21462045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3082776/
Abstract

This study is one of very few that has investigated the neuropsychological functioning of both familial and clinical high risk subjects for psychosis. Participants (N = 164) were members of the Northern Finland 1986 Birth Cohort in the following four groups: familial risk for psychosis (n = 62), clinical risk for psychosis (n = 20), psychosis (n = 13), and control subjects (n = 69). The neurocognitive performance of these groups was compared across 19 cognitive variables. The two risk groups did not differ significantly from controls, but differed from the psychosis group in fine motor function. Neuropsychological impairments were not evident in a non-help-seeking high-risk sample.

摘要

这项研究是少数几项调查精神病家族和临床高危人群神经心理功能的研究之一。参与者（N=164）属于以下四个组的芬兰北部 1986 年出生队列：精神病家族风险（n=62）、精神病临床风险（n=20）、精神病（n=13）和对照组（n=69）。这些组的神经认知表现通过 19 个认知变量进行了比较。这两个风险组与对照组没有显著差异，但在精细运动功能方面与精神病组存在差异。在一个非求助的高风险样本中，并未出现明显的神经心理障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ce/3082776/70693cc55f2b/ncen33-385_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ce/3082776/c6d047ca9080/ncen33-385_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ce/3082776/70693cc55f2b/ncen33-385_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ce/3082776/c6d047ca9080/ncen33-385_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ce/3082776/70693cc55f2b/ncen33-385_f2.jpg

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本文引用的文献

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Arch Gen Psychiatry. 2010 Jun;67(6):578-88. doi: 10.1001/archgenpsychiatry.2010.66.
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Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design.新英格兰家庭研究高危设计中精神分裂症精神病谱系及情感性精神病的家族传递特异性
Arch Gen Psychiatry. 2010 May;67(5):458-67. doi: 10.1001/archgenpsychiatry.2010.38.
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Probably at-risk, but certainly ill--advocating the introduction of a psychosis spectrum disorder in DSM-V.
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The neural underpinnings of associative learning in health and psychosis: how can performance be preserved when brain responses are abnormal?健康和精神病患者联想学习的神经基础：当大脑反应异常时，如何保持表现？
Schizophr Bull. 2010 May;36(3):465-71. doi: 10.1093/schbul/sbq005. Epub 2010 Feb 12.
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Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early--and additional memory dysfunction in the late--prodromal state.不同精神病风险状态下的神经心理学特征：前驱期早期的执行控制损伤——以及前驱期晚期的额外记忆功能障碍。
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