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用潜血试验筛查结直肠癌(作者译)

[Screening for colorectal cancer with the Haemoccult test (author's transl)].

作者信息

Gnauck R

出版信息

Leber Magen Darm. 1977 Feb;7(1):32-5.

PMID:839951
Abstract

Results are reported of a 5 year trial with the Haemoccult stool-test in a diagnostic center (DKD), and of a 1 year trial in the offices of 110 physicians. In the DKD 8 000 patients were tested: In a non-selected group 2,4% and in a selected one 3,8% of tests performed turned out to be positive; the diagnosis of carcinoma of the colon or rectum was established in 32 of these cases and 45 large polyps were traced. In most of the offices the test was positive in less than 3% of the patients tested, 57 of these patients had a carcinoma and 26 polyps. In 54 of all 89 cases with carcinoma and in 46 out of 71 polyps the lesions could not be found by digital or rectoscopic examination, due to a higher localization; 17 of the cancer patients were asymptomatic except for a positive Haemoccult test. Using only 3 tests per patients, 7 out of 96 colorectal cancers and 27 out of 98 large polyps were negative. 6 haemoccult tests to be done on three successive stools (as originally proposed by Greegor) are recommended as a yearly routine procedure in all persons about 40 years of age for early detection of carcinoma or polyps of the colon.

摘要

报告了在一家诊断中心(DKD)对隐血便检进行的5年试验结果,以及在110名医生办公室进行的1年试验结果。在DKD,对8000名患者进行了检测:在一个未经过筛选的组中,2.4%的检测结果呈阳性,在一个经过筛选的组中,3.8%的检测结果呈阳性;在这些病例中,确诊了32例结肠癌或直肠癌,并发现了45个大息肉。在大多数办公室,检测呈阳性的患者不到所检测患者的3%,其中57名患者患有癌症,26名患者患有息肉。在所有89例癌症病例中的54例以及71例息肉中的46例中,由于病变位置较高,通过指检或直肠镜检查未能发现病变;17名癌症患者除隐血检测呈阳性外无任何症状。每位患者仅进行3次检测时,96例结直肠癌中有7例以及98个大息肉中有27个检测结果为阴性。建议对所有40岁左右的人每年进行一次常规检查,连续三次粪便进行6次隐血检测(如Greegor最初提议的那样),以便早期发现结肠癌或息肉。

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