Ohmuro K, Okada K, Satoh A, Murakami K, Satake S, Asahina M, Numakunai S, Ohshima K
Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Morioka, Japan.
J Vet Med Sci. 1993 Aug;55(4):677-80. doi: 10.1292/jvms.55.677.
A thoroughbred horse, gelding, gray color, aged 19 years old had cutaneous melanomas from the root to the middle of the tail, and throughout the connective tissues of the whole body. Histologically, the tumors were diagnosed as mature melanotic melanomas characteristically deposited with abundant melanin pigment. Examined with an electron microscope, melanosomes were electron opaque without internal structure (stage IV), or as mature granular and lamellar types. Most of them were fused with each other, and formed compound melanosomes, which was similar to internal melanin aggregates in shape. The internal melanin aggregates gradually disintegrated, and compound melanosomes grew spherical. The compound melanosomes changed into autophagosomes.
一匹19岁的纯种雄性灰马，从尾巴根部到中部以及全身结缔组织均患有皮肤黑色素瘤。组织学上，肿瘤被诊断为成熟的黑色素性黑色素瘤，其特征是沉积有丰富的黑色素。经电子显微镜检查，黑素小体电子密度高且无内部结构（IV期），或为成熟的颗粒型和板层型。它们大多相互融合，形成复合黑素小体，其形状类似于内部黑色素聚集体。内部黑色素聚集体逐渐解体，复合黑素小体变为球形。复合黑素小体转变为自噬体。
