Fleury C, Bérard F, Balme B, Thomas L
INSERM U346, Laboratoire de Glycobiologie de la Progression Tumorale (appliquée au mélanome), UFR de médecine Lyon Sud-165, Oullins, France.
Pigment Cell Res. 2000 Feb;13(1):39-46. doi: 10.1034/j.1600-0749.2000.130108.x.
The clinical and pathological characteristics of cutaneous melanomas occurring in Camargue-type gray-skinned horses are reported. Examination of 83 tumor-bearing horses revealed that the tumors occurred most frequently underneath the tail (93.9%) and at high rates in the peri-anal region (43.0%), the lips (33.0%), and the eyelids (24.0%), but rarely in the vulva (3.8%). Tumorous lesions were characterized by the presence of either hemispheric nodules or large infiltrated plaques, or their combinations. Microscopic examination indicated that tumorous lesions were composed mostly of melanocytes and numerous melanophages and that component cells manifested a remarkable cellular atypia with anisocytosis and anisokarinosis. Pathological examination of lesions corresponding to earlier stages of the tumors disclosed that tumor formation and its related melanogenesis occurred in close topographical association with apocrine sweat glands, but not at the dermal-epidermal junction. Larger nodules of the tumors were often composed of a concentric deposition of cell layers, each being separated by dermal components from the epidermis. Because of the absence of their tropism toward the epidermis and their multiloculation, horse melanomas are considered to be different in their pathological characteristics from human melanomas.
报告了卡马尔格型灰皮马皮肤黑色素瘤的临床和病理特征。对83匹患肿瘤马的检查发现，肿瘤最常发生在尾巴下方（93.9%），在肛周区域（43.0%）、嘴唇（33.0%）和眼睑（24.0%）的发生率也很高，但在外阴很少见（3.8%）。肿瘤性病变的特征是存在半球形结节或大片浸润性斑块，或两者兼有。显微镜检查表明，肿瘤性病变主要由黑素细胞和大量噬黑素细胞组成，组成细胞表现出明显的细胞异型性，包括细胞大小不等和核大小不等。对肿瘤早期阶段相应病变的病理检查发现，肿瘤形成及其相关的黑素生成与顶泌汗腺在地形上密切相关，但不在真皮-表皮交界处。肿瘤较大的结节通常由细胞层的同心沉积组成，每层都被真皮成分与表皮隔开。由于马黑色素瘤缺乏对表皮的嗜性和多房性，其病理特征被认为与人类黑色素瘤不同。
