Liao S Y, Manetta A
Department of Medicine, University of California, Irvine.
Curr Opin Obstet Gynecol. 1993 Aug;5(4):497-503.
This review focuses on the newly described and redefined benign and malignant lesions of the uterine cervix. The World Health Organization (WHO) classification of the cervix and the Bethesda system are discussed. In addition, the definition of early invasive squamous cell carcinoma is reviewed, and the diagnostic approach, natural history, and oncogenesis of pre-invasive and invasive squamous and glandular lesions are re-examined. The use of human papillomavirus (HPV) DNA detection and its association with cervical intraepithelial neoplasia (CIN) is briefly mentioned. Certain types of benign cervical lesions which mimic neoplasms, including atypical microglandular hyperplasia, and immature papillary metaplasia are mentioned. The unusual subtypes of cervical neoplasm, including villoglandular adenocarcinoma, small cell undifferentiated carcinoma, adenoid basal cell carcinoma, and adenoid cystic carcinoma are reviewed, with emphasis on differential histologic features, as the prognosis for those tumors may differ. Finally, immunohistochemical findings and tumor markers of cervical tumors are briefly mentioned.
本综述聚焦于新描述和重新定义的子宫颈良性和恶性病变。讨论了世界卫生组织（WHO）的子宫颈分类和贝塞斯达系统。此外，回顾了早期浸润性鳞状细胞癌的定义，并重新审视了浸润前和浸润性鳞状及腺性病变的诊断方法、自然史和肿瘤发生机制。简要提及了人乳头瘤病毒（HPV）DNA检测的应用及其与宫颈上皮内瘤变（CIN）的关联。提到了某些模仿肿瘤的良性宫颈病变类型，包括非典型微腺增生和未成熟乳头化生。综述了宫颈肿瘤的不寻常亚型，包括绒毛腺管状腺癌、小细胞未分化癌、腺样基底细胞癌和腺样囊性癌，重点关注组织学鉴别特征，因为这些肿瘤的预后可能不同。最后，简要提及了宫颈肿瘤的免疫组化结果和肿瘤标志物。
