• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Quantitative differences in phagocytosis and degradation of Pneumocystis carinii by alveolar macrophages in AIDS and non-HIV patients in vivo.

作者信息

Wehle K, Schirmer M, Dünnebacke-Hinz J, Küpper T, Pfitzer P

机构信息

Department of Cytopathology, Heinrich Heine University, Düsseldorf, Germany.

出版信息

Cytopathology. 1993;4(4):231-6. doi: 10.1111/j.1365-2303.1993.tb00093.x.

DOI:10.1111/j.1365-2303.1993.tb00093.x
PMID:8400057
Abstract

Bronchoalveolar lavage (BAL) specimens (n = 213) from AIDS and non-HIV immunosuppressed patients were investigated for the presence of Pneumocystis carinii infection by fluorescence microscopy of Papanicolaou-stained slides. Alveolar casts, extracellular pneumocysts and phagocytosed cysts and their degradation products in pulmonary alveolar macrophages were identified. The number of phagocytosed pneumocysts within human pulmonary alveolar macrophages was recorded and correlated with the number of extracellular cysts and alveolar casts, in both groups of patients. Both phagocytic and degradation capacity were depressed in AIDS patients. This observation may explain the large number of extracellular organisms found in BAL specimens of AIDS patients compared with non-HIV-positive immunocompromised individuals.

摘要

相似文献

1
Quantitative differences in phagocytosis and degradation of Pneumocystis carinii by alveolar macrophages in AIDS and non-HIV patients in vivo.
Cytopathology. 1993;4(4):231-6. doi: 10.1111/j.1365-2303.1993.tb00093.x.
2
Identification of phagocytosed Pneumocystis carinii in human pulmonary alveolar macrophages.人肺泡巨噬细胞中吞噬的卡氏肺孢子虫的鉴定。
Cytopathology. 1993;4(4):225-9. doi: 10.1111/j.1365-2303.1993.tb00092.x.
3
The diagnosis of Pneumocystis carinii pneumonia by cytologic evaluation of Papanicolaou and Leishman-stained bronchoalveolar specimens in patients with the acquired immunodeficiency syndrome.通过对获得性免疫缺陷综合征患者经巴氏染色和利什曼染色的支气管肺泡标本进行细胞学评估来诊断卡氏肺孢子虫肺炎。
Cytopathology. 1993;4(2):77-84. doi: 10.1111/j.1365-2303.1993.tb00518.x.
4
Pneumocystis carinii enhances soluble mannose receptor production by macrophages.卡氏肺孢子虫可增强巨噬细胞可溶性甘露糖受体的产生。
Microbes Infect. 2000 Sep;2(11):1305-10. doi: 10.1016/s1286-4579(00)01283-1.
5
Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation.感染HIV-1的人肺泡巨噬细胞对卡氏肺孢子虫的结合和吞噬作用降低，这与甘露糖受体下调有关。
J Clin Invest. 1998 Oct 1;102(7):1332-44. doi: 10.1172/JCI560.
6
The cytological diagnosis of Pneumocystis carinii by fluorescence microscopy of Papanicolaou stained bronchoalveolar lavage specimens.通过巴氏染色支气管肺泡灌洗标本的荧光显微镜检查对卡氏肺孢子虫进行细胞学诊断。
Cytopathology. 1991;2(3):113-20. doi: 10.1111/j.1365-2303.1991.tb00395.x.
7
Pulmonary alveolar proteinosis associated with Pneumocystis carinii. Ultrastructural identification in bronchoalveolar lavage in AIDS and immunocompromised non-AIDS patients.与卡氏肺孢子虫相关的肺泡蛋白沉积症。艾滋病患者及免疫功能低下的非艾滋病患者支气管肺泡灌洗中的超微结构鉴定
Chest. 1990 Oct;98(4):801-5. doi: 10.1378/chest.98.4.801.
8
Surfactant protein D-mediated aggregation of Pneumocystis carinii impairs phagocytosis by alveolar macrophages.表面活性蛋白D介导的卡氏肺孢子虫聚集会损害肺泡巨噬细胞的吞噬作用。
Infect Immun. 2003 Apr;71(4):1662-71. doi: 10.1128/IAI.71.4.1662-1671.2003.
9
Ultrastructural observation of Pneumocystis carinii in bronchoalveolar lavage fluid from non-AIDS patients with P carinii pneumonia.
Chest. 1994 May;105(5):1342-6. doi: 10.1378/chest.105.5.1342.
10
Case report: hypercalcemia in a patient with AIDS and Pneumocystis carinii pneumonia.
Am J Med Sci. 1993 Nov;306(5):313-6. doi: 10.1097/00000441-199311000-00008.

引用本文的文献

1
Alveolar Macrophage Dysfunction and Increased PD-1 Expression During Chronic SIV Infection of Rhesus Macaques.慢性 SIV 感染恒河猴期间肺泡巨噬细胞功能障碍和 PD-1 表达增加。
Front Immunol. 2019 Jul 3;10:1537. doi: 10.3389/fimmu.2019.01537. eCollection 2019.
2
Small alveolar macrophages are infected preferentially by HIV and exhibit impaired phagocytic function.小肺泡巨噬细胞优先被HIV感染，并表现出吞噬功能受损。
Mucosal Immunol. 2014 Sep;7(5):1116-26. doi: 10.1038/mi.2013.127. Epub 2014 Jan 29.
3
Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia.
免疫调节用柳氮磺胺吡啶可减轻免疫发病机制，但增强卡氏肺孢子虫肺炎期间巨噬细胞介导的真菌清除。
PLoS Pathog. 2010 Aug 19;6(8):e1001058. doi: 10.1371/journal.ppat.1001058.
4
Pneumocystis carinii-induced activation of the respiratory burst in human monocytes and macrophages.卡氏肺孢子虫诱导人单核细胞和巨噬细胞呼吸爆发的激活。
Clin Exp Immunol. 1994 Nov;98(2):196-202. doi: 10.1111/j.1365-2249.1994.tb06125.x.