Birchmeier W, Weidner K M, Hülsken J, Behrens J
Institute of Cell Biology (Tumor Research), University of Essen Medical School, Germany.
Semin Cancer Biol. 1993 Aug;4(4):231-9.
It has been realized for some time that the loss of epithelial differentiation in carcinomas, which is accompanied by higher mobility and invasiveness of the tumor cells, is a consequence of reduced intercellular adhesion. A variety of recent reports have indicated that the primary cause for the 'scattering' of the cells in invasive carcinomas is a loss of the integrity of intercellular adherens junctions often involving loss of a functional cell-cell adhesion molecule E-cadherin. In the present review, permanent and transient molecular mechanisms are discussed which lead to the impairment of junctional integrity of cells and thus the progression of carcinomas toward a more metastatic state.
一段时间以来人们已经认识到，在癌中上皮分化的丧失，伴随着肿瘤细胞更高的迁移性和侵袭性，是细胞间黏附减少的结果。最近的各种报告表明，浸润性癌中细胞“分散”的主要原因是细胞间黏附连接完整性的丧失，这通常涉及功能性细胞间黏附分子E-钙黏蛋白的丧失。在本综述中，讨论了导致细胞连接完整性受损从而使癌发展为更具转移性状态的永久性和暂时性分子机制。
