Sosnovskiĭ A S, Kubatiev A A
Biull Eksp Biol Med. 1993 Jul;116(7):40-2.
In August rats, 24-h immobilization stress (IS) decreased the rate and amplitude of platelet aggregation induced by collagen (2-4 microgram/ml) or ADR (0.25-5.0 microM) in platelet-rich plasma, but had no effect on ATP release reaction. Platelet aggregability unchanged in groups deprived of food and water for 24 h or subjected to 6-h IS. Only after 24-h IS were the effects of collagen and low concentrations of ADP potentiated by preincubation of platelets with epinephrine (1 microM). The IS-induced decrease in platelet aggregation to 2 micrograms/ml collagen correlated significantly with the thymus involution, and both effects were most pronounced in rats displaying low activity scores in a hole-board apparatus. The data strongly implicate behavioral variables in the stress-induced changes in platelet functions.
在八月龄大鼠中，24小时制动应激（IS）降低了富含血小板血浆中由胶原蛋白（2 - 4微克/毫升）或肾上腺素（0.25 - 5.0微摩尔）诱导的血小板聚集速率和幅度，但对ATP释放反应没有影响。禁食和禁水24小时或经历6小时制动应激的组中血小板聚集能力未改变。仅在24小时制动应激后，用肾上腺素（1微摩尔）预孵育血小板可增强胶原蛋白和低浓度ADP的作用。IS诱导的血小板对2微克/毫升胶原蛋白聚集的降低与胸腺退化显著相关，并且在洞板实验中活动评分低的大鼠中这两种效应最为明显。数据强烈表明行为变量参与了应激诱导的血小板功能变化。
