Musso R, Russo M, Raimondo V
Boll Soc Ital Biol Sper. 1980 Mar 30;56(6):569-75.
Since there is evidence of the correlation between the platelet membrane phospholipids and the aggregating properties of several agents, we studied in vitro the effect of Free Fatty Acids (FFA) on ADP, collagen and epinephrine-induced platelet aggregation. Our results showed that "sub-critical" concentrations of long carbon chains of saturated and unsaturated FFA potentiated the platelet aggregation induced by "critical" concentrations of ADP, collagen and epinephrine. However, we suggest that exogenous long carbon chains of FFA could enhance the platelet membrane lipids and could make the platelets more "responsive" or "sensitive" to lowest aggregating stimuli.
由于有证据表明血小板膜磷脂与几种药物的聚集特性之间存在相关性，我们在体外研究了游离脂肪酸（FFA）对ADP、胶原蛋白和肾上腺素诱导的血小板聚集的影响。我们的结果表明，饱和和不饱和FFA的长碳链“亚临界”浓度增强了由“临界”浓度的ADP、胶原蛋白和肾上腺素诱导的血小板聚集。然而，我们认为外源性FFA的长碳链可以增强血小板膜脂质，并使血小板对最低聚集刺激更“敏感”或“有反应”。
