[The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency].

Experiments in rats with different sensitivity to hypobaric hypoxia established bimodal distribution of antipyrine and isoniazide half-lives. Moreover, the low-sensitive rats were rapid acetylators and slow oxidizers, but the high-sensitive ones vice versa. The slowing down of antipyrine and isoniazide metabolism is supposed to be the most rational reaction of oxygen-dependent systems to the lack of oxygen in tissues.