Zha L L
Inst. of the Integr. of TCM-WM Med., Shanghai Med. Univ.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Apr;13(4):202-4, 195.
32 cases of hypothyroidism caused by various factors were treated for one year with Chinese medicinal herbs preparation "Shen Lu tablet" (SLT) to warm and reinforce the Kidney Yang. 34 normal persons were studied as a control group. After treatment with SLT, the clinical symptoms of hypothyroidism were markedly improved. Average serum concentration of total T3, T4 increased significantly from 67.06 +/- 4.81 and 3.29 +/- 0.42 before treatment to 120.50 +/- 6.34 ng/dl and 6.31 +/- 0.38 micrograms/dl, respectively (P < 0.001). Serum levels of TSH decreased evidently from 20.81 +/- 2.78 before therapy to 3.32 +/- 0.61 ng/ml (P < 0.001). Before treatment with SLT, hypothyroidism group had higher erythrocyte sodium content ([Na]Rbc) than that of normal group. The permeability of the cell membrane oMNaos and the activity of sodium pump oKNaos in intact erythrocytes were markedly lower in the treated group than that in the normal group. In hypothyroidism patients treated by SLT the [Na]Rbc significantly dropped, and the oNNaos and oKNaos were significantly raised when compared with those before treatment, P < 0.001. It is suggested that hypothyroidism was closely related with Deficiency of Kidney Yang and energy metabolism.
应用补肾壮阳的中药制剂“参芦片”（SLT）对32例由各种因素引起的甲状腺功能减退症患者进行了为期一年的治疗。以34名正常人作为对照组。经参芦片治疗后，甲状腺功能减退症的临床症状明显改善。血清总T3、T4平均浓度分别从治疗前的67.06±4.81和3.29±0.42显著升高至120.50±6.34 ng/dl和6.31±0.38μg/dl（P<0.001）。血清促甲状腺激素（TSH）水平从治疗前的20.81±2.78明显降至3.32±0.61 ng/ml（P<0.001）。在应用参芦片治疗前，甲状腺功能减退症组红细胞钠含量（[Na]Rbc）高于正常组。治疗组完整红细胞的细胞膜钠通透性（oMNaos）和钠泵活性（oKNaos）明显低于正常组。经参芦片治疗的甲状腺功能减退症患者，其[Na]Rbc显著下降，oNNaos和oKNaos与治疗前相比显著升高，P<0.001。提示甲状腺功能减退症与肾阳虚及能量代谢密切相关。
