Land J M, Kemp G J, Taylor D J, Standing S J, Radda G K, Rajagopalan B
Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, U.K.
Neuromuscul Disord. 1993 May;3(3):223-5. doi: 10.1016/0960-8966(93)90063-p.
A 57-yr-old man presented with a long history of undiagnosed fatigue but no evidence of bone disease. He was noted to have hypophosphatemia due to an idiopathic phosphaturia. Marked abnormalities of exercising skeletal muscle detected by phosphorus magnetic resonance spectroscopy and by plasma metabolite measurements were consistent with mitochondrial dysfunction. Oral phosphate supplements restored plasma phosphate concentration and muscle biochemistry to normal and produced considerable improvement in symptoms and exercise tolerance, although the phosphate concentration in muscle was only marginally low and increased little by treatment. We conclude that hypophosphatemia should be excluded in unexplained fatigue.
一名57岁男性，长期存在未确诊的疲劳症状，但无骨病证据。他因特发性磷尿症出现低磷血症。通过磷磁共振波谱和血浆代谢物测量检测到的运动骨骼肌明显异常与线粒体功能障碍一致。口服磷酸盐补充剂使血浆磷酸盐浓度和肌肉生化指标恢复正常，并使症状和运动耐量有了显著改善，尽管肌肉中的磷酸盐浓度仅略低，且治疗后升高幅度不大。我们得出结论，在不明原因的疲劳中应排除低磷血症。
