Trooster W J, Teelken A W, Kampinga J, Loof J G, Nieuwenhuis P, Minderhoud J M
Department of Neurology, University of Groningen, The Netherlands.
Int Arch Allergy Immunol. 1993;102(2):133-40. doi: 10.1159/000236563.
Induction of experimental allergic encephalomyelitis (EAE) in female Lewis rats led to the well-known clinical symptoms and histological signs. Treatment with the synthetic estrogen 17-alpha-ethinylestradiol (EE) from day -4 before induction until day 21 after induction resulted in partial suppression of these signs and symptoms. Analysis of the peripheral blood leukocyte (sub)populations in these treated animals indicated some remarkable changes. However, these changes were also observed without EE treatment. EE treatment of EAE rats resulted in a significant decrease of the relative weights of both thymus and spleen, which changes however were not reflected in the peripheral blood. Apparently the effects of EE treatment on EAE in the present experiments indicate an action locally at the site of the EAE lesion and do not seem to be mediated by gross changes in the levels of peripheral blood leukocytes.
在雌性Lewis大鼠中诱导实验性自身免疫性脑脊髓炎（EAE）会导致众所周知的临床症状和组织学体征。从诱导前第4天至诱导后第21天用合成雌激素17-α-乙炔雌二醇（EE）进行治疗，可部分抑制这些体征和症状。对这些接受治疗动物的外周血白细胞（亚）群分析显示出一些显著变化。然而，在未进行EE治疗的情况下也观察到了这些变化。用EE治疗EAE大鼠会导致胸腺和脾脏的相对重量显著降低，不过这些变化在外周血中并未体现出来。显然，在本实验中EE治疗EAE的效果表明其在EAE病变部位具有局部作用，似乎并非由外周血白细胞水平的总体变化介导。
