原发性血小板增多症巨核母细胞转化病例中原始细胞的细胞质糖蛋白IIb-IIIa及细胞因子分泌
Cytoplasmic GpIIb-IIIa and cytokine secretion by blasts in a case of megakaryoblastic transformation of essential thrombocythemia.
作者信息
Selleri C, Alfinito F, Del Vecchio L, Luciano L, De Renzo A, Rotoli B
机构信息
Division of Hematology, 2nd Medical School, University of Naples, Italy.
出版信息
Leuk Lymphoma. 1993 Aug;10(6):497-500. doi: 10.3109/10428199309148209.
A 49-year-old woman with a four year history of therapy resistant essential thrombocythemia, progressed to acute leukemia that also proved refractory to chemotherapy. Blast cell features including immunophenotype, cytogenetics and in vitro cell cultures, suggested megakaryoblastic leukemia. In serum-free culture, blasts released GM-CSF and IL-6 which sustained autocrine growth and promoted normal myeloid and megakaryocytic colony formation.
一名49岁女性，有四年治疗抵抗性原发性血小板增多症病史，病情进展为急性白血病，化疗也无效。原始细胞特征包括免疫表型、细胞遗传学和体外细胞培养，提示为巨核细胞白血病。在无血清培养中，原始细胞释放粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-6（IL-6），维持自分泌生长并促进正常髓系和巨核细胞集落形成。
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