9个人类22号染色体长臂位点在实验小鼠中的比较定位。
Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse.
作者信息
Bućan M, Gatalica B, Nolan P, Chung A, Leroux A, Grossman M H, Nadeau J H, Emanuel B S, Budarf M
机构信息
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104.
出版信息
Hum Mol Genet. 1993 Aug;2(8):1245-52. doi: 10.1093/hmg/2.8.1245.
We present a comparative map of genes on human chromosome 22q and homologous loci in the mouse genome. Gene order in humans was established using a panel of somatic cell hybrids. Genetic maps spanning homologous segments on three mouse chromosomes were generated using an interspecific backcross. The conserved linkage between human chromosome 22 and mouse chromosome 16 includes two closely linked loci, Comt and IgI-1. The second conserved linkage involves human chromosome 22 and mouse chromosome 11 and contains two genetically and physically linked loci, Lif and Nfh. Finally, conserved synteny involving mouse chromosome 15 and human chromosome 22 spans 30 cM and contains five loci (Acr, Bzrp, Dia-1, Il2rb and Pdgfb). Loci within this conserved synteny have been sublocalized to different portions of human chromosome 22. The order of genes on mouse chromosome 15 and human chromosome 22 provides further evidence for chromosomal rearrangements within the conserved synteny that have occurred since the divergence of lineages leading to mice and humans.
我们展示了人类22号染色体上的基因与小鼠基因组中同源位点的比较图谱。人类的基因顺序是利用一组体细胞杂种确定的。使用种间回交生成了跨越三条小鼠染色体上同源片段的遗传图谱。人类22号染色体与小鼠16号染色体之间的保守连锁包括两个紧密连锁的位点，即儿茶酚-O-甲基转移酶（Comt）和免疫球蛋白I-1（IgI-1）。第二个保守连锁涉及人类22号染色体和小鼠11号染色体，并包含两个遗传和物理上连锁的位点，即白血病抑制因子（Lif）和神经丝重链（Nfh）。最后，涉及小鼠15号染色体和人类22号染色体的保守同线性跨度为30厘摩，包含五个位点（酰基辅酶A还原酶（Acr）、苯并二氮杂卓受体结合蛋白（Bzrp）、肌动蛋白结合蛋白1（Dia-1）、白细胞介素2受体β链（Il2rb）和血小板衍生生长因子β（Pdgfb））。这个保守同线性内的位点已被定位到人类22号染色体的不同部分。小鼠15号染色体和人类22号染色体上基因的顺序为自导致小鼠和人类的谱系分化以来在保守同线性内发生的染色体重排提供了进一步的证据。
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