Pay A, Jonak C, Bögre L, Meskiene I, Mairinger T, Szalay A, Heberle-Bors E, Hirt H
Institute of Microbiology and Genetics, University of Vienna, Austria.
Plant J. 1993 Jun;3(6):847-56. doi: 10.1111/j.1365-313x.1993.00847.x.
This paper reports on the isolation of a novel class of plant serine/threonine protein kinase genes, MsK-1, MsK-2 and MsK-3. They belong to the superfamily of cdc2-like genes, but show highest identity to the Drosophila shaggy and rat GSK-3 proteins (65-70%). All of these kinases share a highly conserved catalytic protein kinase domain. Different amino-terminal extensions distinguish the different proteins. The different plant kinases do not originate from differential processing of the same gene as is found for shaggy, but are encoded by different members of a gene family. Similarly to the shaggy kinases, the plant kinases show different organ-specific and stage-specific developmental expression patterns. Since the shaggy kinases play an important role in intercellular communication in Drosophila development, the MsK kinases are expected to perform a similar function in plants.
本文报道了一类新型植物丝氨酸/苏氨酸蛋白激酶基因MsK - 1、MsK - 2和MsK - 3的分离。它们属于类cdc2基因超家族，但与果蝇的shaggy蛋白和大鼠的GSK - 3蛋白具有最高的同源性（65 - 70%）。所有这些激酶都共享一个高度保守的催化蛋白激酶结构域。不同的氨基末端延伸区分了不同的蛋白质。不同的植物激酶并非如shaggy蛋白那样源自同一基因的差异加工，而是由一个基因家族的不同成员编码。与shaggy激酶类似，植物激酶表现出不同的器官特异性和阶段特异性发育表达模式。由于shaggy激酶在果蝇发育的细胞间通讯中起重要作用，预计MsK激酶在植物中执行类似功能。
