Hoły Z, Braszko J, Wiśniewski K
Department of Pharmacology, Medical Academy, Białystok, Poland.
Pol J Pharmacol. 1993 Jan-Feb;45(1):31-41.
In this study the effects of angiotensin II (AII) angiotensin II hexapeptide [AII(1-6)] and angiotensin II pentapeptide [AII(2-6)] on the motility, stereotypy, learning of conditioned avoidance responses (CARs) and recall of a passive behavior making it possible to avoid aversive stimulation in rats, were compared. All the peptides were injected into the lateral cerebral ventricle (icv) in a dose of 1 nmol. AII caused a statistically significant increase in the number of crossings, rearings, and bar approaches in an open field whereas [AII(1-6)] and [AII(2-6)] were inactive in this test. The stereotypic behavior induced by an intraperitoneal (ip) injection of apomorphine (1 mg/kg) and amphetamine (7.5 mg/kg) was statistically significantly enhanced only in the rats which received AII icv. The application of AII, but not that of [AII(1-6)] and [AII(2-6)] resulted in a quicker acquisition of the CARs. A better recall of passive avoidance was achieved only by AII, while the fragments [AII(1-6)] and [AII(2-6)] had no effect. These findings indicate that the 1-6 and 2-6 fragments of AII do not possess a psychotropic activity like that of the parent octapeptide.
在本研究中，比较了血管紧张素II（AII）、血管紧张素II六肽[AII(1 - 6)]和血管紧张素II五肽[AII(2 - 6)]对大鼠运动性、刻板行为、条件性回避反应（CARs）学习以及被动行为记忆（从而能够避免厌恶性刺激）的影响。所有肽均以1 nmol的剂量注入侧脑室（icv）。AII使旷场实验中的穿越次数、直立次数和触棒次数在统计学上显著增加，而[AII(1 - 6)]和[AII(2 - 6)]在此测试中无活性。腹腔注射阿扑吗啡（1 mg/kg）和苯丙胺（7.5 mg/kg）诱导的刻板行为仅在接受AII icv注射的大鼠中在统计学上显著增强。AII的应用导致CARs的更快获得，而[AII(1 - 6)]和[AII(2 - 6)]则无此作用。仅AII能更好地恢复被动回避，而[AII(1 - 6)]和[AII(2 - 6)]片段则无影响。这些发现表明，AII的1 - 6和2 - 6片段不具有像母体八肽那样的精神活性。
