Wiśniewski K, Hoły Z
Department of Pharmacology, Medical School, Białystok, Poland.
J Physiol Pharmacol. 1995 Jun;46(2):141-50.
In this work we compared the influence of sodium nitroprusside [SNP] (a NO donor) on behavioural effects of angiotensin II [AII] in rats. The motility, stereotypy, learning of conditioned avoidance responses and recall of passive avoidance behaviour allowing to avoid aversive stimulation were estimated. The intracerebroventricularly injection--15 min before the experiment--of AII, SNP and AII combined with SNP did not produce changes in psychomotor activity in open field, not significantly accelerated acquisition of conditioned avoidance responses and significantly improved recall of the passive avoidance. AII, SNP and AII with SNP applied immediately before the experiment intensified stereotypy evoked by apomorphine in the dose of 1 mg/kg and amphetamine in the dose of 7.5 mg/kg given intraperitoneally. These results show that; 1) sodium nitroprusside as a donor NO participates in memory and learning processes, 2) overproduction of NO did not change behavioural effects of AII in these experiments.
在本研究中，我们比较了硝普钠[SNP]（一种一氧化氮供体）对血管紧张素II [AII]在大鼠行为效应方面的影响。评估了运动性、刻板行为、条件性回避反应的学习以及允许避免厌恶刺激的被动回避行为的记忆。在实验前15分钟脑室内注射AII、SNP以及AII与SNP的组合，未引起旷场实验中精神运动活动的变化，未显著加速条件性回避反应的习得，且显著改善了被动回避的记忆。在实验前立即应用AII、SNP以及AII与SNP，增强了由腹腔注射1 mg/kg剂量的阿扑吗啡和7.5 mg/kg剂量的苯丙胺所诱发的刻板行为。这些结果表明：1）硝普钠作为一氧化氮供体参与记忆和学习过程；2）在这些实验中，一氧化氮的过量产生并未改变AII的行为效应。
