Hoły Z, Braszko J, Kupryszewski G, Witczuk B, Wiśniewski K
Department of Pharmacology, Medical Academy in Białystok.
J Physiol Pharmacol. 1992 Jun;43(2):183-92.
In this work we compared in rats the influence of heptapeptide 1-7-angiotensin II, hexapeptide 2-7-angiotensin II, pentapeptide 3-7-angiotensin II and angiotensin II on motility, stereotypy, learning of conditioned avoidance responses and recall of passive avoidance behaviour allowing to avoid aversive stimulation. The 4 peptides administered 15 min before the experiment, tended to increase the number of crossings, rearings and bar approaches in open field, significantly accelerated acquisition of conditioned avoidance responses and improved recall of the passive avoidance. All the peptides applied immediately before the experiment intensified stereotypy evoked by apomorphine in the dose 1 mg/kg and amphetamine in the dose 6.5 mg/kg given intraperitoneally. These results show full psychotropic activity of the examined fragments of angiotensin II, comparable with the activity of the parent octapeptide. Our previous hypothesis that the Val-Tyr-Ile-His-Pro fragment of angiotensin II is responsible for the psychotropic activity evoked by angiotensins in rats is thus confirmed.
在本研究中，我们比较了七肽1 - 7 - 血管紧张素II、六肽2 - 7 - 血管紧张素II、五肽3 - 7 - 血管紧张素II和血管紧张素II对大鼠运动性、刻板行为、条件性回避反应学习以及被动回避行为记忆（以避免厌恶刺激）的影响。在实验前15分钟给予这4种肽，它们往往会增加在旷场试验中的穿越次数、直立次数和触棒次数，显著加速条件性回避反应的习得，并改善被动回避的记忆。在实验前立即应用的所有肽，均增强了腹腔注射1mg/kg阿扑吗啡和6.5mg/kg苯丙胺所诱发的刻板行为。这些结果表明，所检测的血管紧张素II片段具有完全的精神活性，与母体八肽的活性相当。因此，我们之前关于血管紧张素II的缬氨酸 - 酪氨酸 - 异亮氨酸 - 组氨酸 - 脯氨酸片段负责大鼠体内血管紧张素所诱发的精神活性的假设得到了证实。
