Filip M, Chojnacka-Wójcik E, Przegaliński E
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Pol J Pharmacol. 1993 Mar-Apr;45(2):151-6.
Using a drug discrimination procedure on a fixed ratio (FR) 10 schedule of reinforcement, rats were trained to distinguish between the stimulus properties of the selective inhibitor of noradrenaline uptake (+)-oxaprotiline ((+)-OXA) and saline. Fifty per cent of the rats that learned to reliably discriminate (+)-OXA from saline, reached high discrimination accuracy. In substitution testing, maprotiline (MAP) and desipramine (DMI) produced dose-related responding on the (+)-OXA lever. (-)-OXA failed to show substitution. The results of our findings demonstrate that (+)-OXA may be used as a discriminative cue in rats. The NA uptake inhibition seems to be involved in the effect of this drug.
在固定比率（FR）10强化程序下使用药物辨别程序，训练大鼠区分去甲肾上腺素摄取选择性抑制剂（+）-奥沙普明（（+）-OXA）和生理盐水的刺激特性。学会可靠区分（+）-OXA和生理盐水的大鼠中有50%达到了高辨别准确率。在替代测试中，马普替林（MAP）和地昔帕明（DMI）在（+）-OXA杆上产生了剂量相关反应。（-）-OXA未显示替代作用。我们的研究结果表明，（+）-OXA可用作大鼠的辨别线索。去甲肾上腺素摄取抑制似乎与该药物的作用有关。
