Neary D, Snowden J S, Mann D M
Department of Neurology, Manchester Royal Infirmary, UK.
Dementia. 1993 May-Aug;4(3-4):154-9. doi: 10.1159/000107315.
Three clinical syndromes associated with fronto-temporal cerebral atrophy, studied in one centre are discussed: dementia of frontal type (DFT), DFT and motor neurone disease (MND) and progressive aphasia (PA). The pathological findings in DFT (13 brains), DFT and MND (5 brains) and PA (5 brains) permit a number of clinical pathological groupings. The nosological status of fronto-temporal atrophy is discussed with reference to the literature and it is suggested that a common underlying pathology, including Picks disease as strictly defined by the presence of inclusion bodies, underlies the clinical syndromes, each being determined by the anatomical distribution of the pathology.
额型痴呆（DFT）、DFT与运动神经元病（MND）以及进行性失语（PA）。对DFT（13例脑标本）、DFT与MND（5例脑标本）以及PA（5例脑标本）的病理检查结果进行分析，可得出一些临床病理分类。结合文献探讨了额颞叶萎缩的疾病分类情况，并提出一种共同的潜在病理改变（包括严格依据包涵体定义的匹克病）是这些临床综合征的基础，每种综合征由病理改变的解剖分布所决定。
