Frisoni G B, Beltramello A, Geroldi C, Weiss C, Bianchetti A, Trabucchi M
Alzheimer's Unit, S Cuore-FBF Hospital, Brescia, Italy.
J Neurol Neurosurg Psychiatry. 1996 Aug;61(2):157-65. doi: 10.1136/jnnp.61.2.157.
To evaluate the pattern of regional brain atrophy in patients with frontotemporal dementia by comparing it with that in patients with Alzheimer's disease and normal controls.
Fourteen patients with frontotemporal dementia, 13 with moderate, and 33 with mild Alzheimer's disease, and 31 controls were studied. Atrophy was evaluated with linear measures in the anterior brain, medial temporal lobe, and hippocampal formation regions using MRI.
Patients with frontotemporal dementia had greater atrophy in the anterior brain regions than patients with Alzheimer's disease or controls. Atrophy of the hippocampal formation, which best discriminates Alzheimer's disease from controls, was present also in patients with frontotemporal dementia. By contrast, atrophy of the medial temporal lobe, which is also present in Alzheimer's disease, was absent in frontotemporal dementia.
A pattern of atrophy in the frontal lobes and hippocampal formation with sparing of the medial temporal lobe might be distinctive of frontotemporal dementia. Hippocampal involvement might not be specific for Alzheimer's disease and specific patterns of atrophy might be distinctive of some forms of degenerative dementia.
通过将额颞叶痴呆患者的脑区萎缩模式与阿尔茨海默病患者及正常对照者进行比较，以评估其特征。
对14例额颞叶痴呆患者、13例中度和33例轻度阿尔茨海默病患者以及31名对照者进行研究。使用MRI通过线性测量法评估前脑、内侧颞叶和海马结构区域的萎缩情况。
额颞叶痴呆患者在前脑区域的萎缩程度比阿尔茨海默病患者或对照者更严重。海马结构萎缩是将阿尔茨海默病与对照者区分开来的最佳指标，在额颞叶痴呆患者中也存在。相比之下，内侧颞叶萎缩在阿尔茨海默病中也存在，但在额颞叶痴呆中不存在。
额叶和海马结构萎缩而内侧颞叶未受累的模式可能是额颞叶痴呆的特征。海马受累可能并非阿尔茨海默病所特有，特定的萎缩模式可能是某些形式的退行性痴呆的特征。
