De Craemer D, Pauwels M, Vergeylen A, Roels F, Van den Branden C
Menselijke Anatomie and Embryologie, Vrije Universiteit Brussel, Belgium.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64(1):7-12. doi: 10.1007/BF02915090.
In the liver, kidney and duodenum of nude mice with xenografts of two human pancreatic adenocarcinomas differing in growth rate, catalase activity was assayed and peroxisomes were studied using catalase cytochemistry and light and electron microscopy. Hepatic and duodenal catalase activity were significantly decreased in tumour-bearing mice. Renal catalase activity was unchanged. At light microscopic level, a decrease in peroxisomal staining was evident in all duodenums and most livers of tumour-bearing mice. Only minor changes were observed in the kidneys. Ultrastructural morphometry of the hepatocellular peroxisomes revealed a decrease in size, volume density and surface density only in mice with fast-growing xenografts. These observations indicate that the two pancreatic adenocarcinomas exerted a different effect on the hepatic peroxisomes, and that catalase activity and peroxisomes in liver and duodenum are more affected than in kidney.
在移植了两种生长速率不同的人胰腺腺癌的裸鼠的肝脏、肾脏和十二指肠中，测定了过氧化氢酶活性，并使用过氧化氢酶细胞化学以及光学和电子显微镜研究了过氧化物酶体。荷瘤小鼠的肝脏和十二指肠过氧化氢酶活性显著降低。肾脏过氧化氢酶活性未发生变化。在光学显微镜水平上，荷瘤小鼠的所有十二指肠和大多数肝脏中过氧化物酶体染色明显减少。在肾脏中仅观察到微小变化。肝细胞过氧化物酶体的超微结构形态计量学显示，仅在移植了快速生长异种移植物的小鼠中，过氧化物酶体的大小、体积密度和表面密度有所降低。这些观察结果表明，这两种胰腺腺癌对肝脏过氧化物酶体产生了不同的影响，并且肝脏和十二指肠中的过氧化氢酶活性和过氧化物酶体比肾脏中的更易受到影响。
