Terranova V P
Columbia University, New York.
Curr Opin Periodontol. 1993:129-35.
Cells in normal tissue progress through programs of growth, differentiation, and death. Many of the signals that start and stop this process are initiated by growth factors produced by other cells or by the resident cells. This network of intercellular signaling represents the basis for establishing and maintaining normal tissue architecture. Growth factors are released by some cells and conveyed to target cells, where they are bound to specific receptors, triggering a complex signal transduction cascade. Human periodontal ligament cells have been shown by in vitro assays to respond both mitogenically and chemotactically to a variety of growth factors including, but not limited to, platelet-derived growth factor, basic fibroblast growth factor, and transforming growth factor-beta. Evidence is presented for confirmation of an autocrine chemotactic and mitogenic human periodontal ligament cell-specific factor. This type of knowledge suggests that future periodontal regeneration procedures will rely on the exogenous addition of specific growth factors.
正常组织中的细胞经历生长、分化和死亡程序。启动和停止这一过程的许多信号是由其他细胞或驻留细胞产生的生长因子引发的。这种细胞间信号网络是建立和维持正常组织结构的基础。生长因子由一些细胞释放并传递到靶细胞，在靶细胞中它们与特定受体结合，触发复杂的信号转导级联反应。体外试验表明，人牙周膜细胞对多种生长因子有丝裂原性和趋化性反应，包括但不限于血小板衍生生长因子、碱性成纤维细胞生长因子和转化生长因子-β。有证据证实了一种自分泌趋化和有丝分裂的人牙周膜细胞特异性因子。这类知识表明，未来的牙周再生程序将依赖于外源性添加特定的生长因子。
