J Periodontol. 1996 May;67(5):545-53.
Polypeptide growth and differentiation factors (GDFs) are a class of biological mediators which have been shown to play a critical role in the stimulation and regulation of the wound healing process. Growth factors involved in repair and regeneration regulate several key cellular processes such as mitogenesis, chemotaxis, differentiation, and metabolism. The sequence of events necessary for periodontal regeneration relies on the above processes for osteogenesis, cementogenesis, and connective tissue formation. Numerous preclinical in vitro and in vivo studies have demonstrated that certain growth factors modulate putative components of periodontal wound healing resulting in substantial regeneration of the periodontium in animals. However, these therapies are currently considered to be in the experimental stage of development and no growth factor therapy to treat periodontitis in humans has received approval by the Food and Drug Administration (FDA). This informational paper reviews the various aspects of GDFs on cells and tissues involved in periodontal wound healing. This paper was prepared by the Committee on Research, Science and Therapy of The American Academy of Periodontology and is intended for members of the dental profession.
多肽生长与分化因子（GDFs）是一类生物介质，已被证明在刺激和调节伤口愈合过程中起关键作用。参与修复和再生的生长因子调节几个关键的细胞过程，如细胞增殖、趋化性、分化和代谢。牙周再生所需的一系列事件依赖于上述成骨、牙骨质生成和结缔组织形成过程。大量临床前的体外和体内研究表明，某些生长因子可调节牙周伤口愈合的假定成分，从而在动物体内实现牙周组织的大量再生。然而，目前这些疗法仍处于研发的实验阶段，尚无用于治疗人类牙周炎的生长因子疗法获得美国食品药品监督管理局（FDA）的批准。本信息文件综述了GDFs对参与牙周伤口愈合的细胞和组织的各个方面的影响。本文由美国牙周病学会研究、科学与治疗委员会编写，供牙科专业人员阅读。
