Munson R J, Goodhead D T
Mutat Res. 1977 Feb;42(2):145-60. doi: 10.1016/s0027-5107(77)80019-5.
Many mutagens are known to induce a variety of different types of lesions in DNA. Cellular repair systems may eliminate some of these; some unrepaired lesions may lead to loss of reproductive capacity and others to viable mutations. Simple considerations of these three alternative fates of an exposed cell show that there should be a linear relation between the logarithm of the surviving fraction (log S/SO) and log (1-M) where M is the mutant frequency. For low frequencies the relation assumes the simpler form M=-m log S/SO. The published literature on experimental mutagenesis in eukaryotes confirms these expectations. Observed differences in the slope m when different mutagens induce the same mutation in a given kind of cell (or a given mutagen induces the same mutation in different kinds of cell) imply that mutation and cellular inactivation do not arise from one type of DNA lesion only.
已知许多诱变剂可在DNA中诱导多种不同类型的损伤。细胞修复系统可能会消除其中一些损伤；一些未修复的损伤可能导致生殖能力丧失，而另一些则导致存活突变。对暴露细胞的这三种不同命运的简单思考表明，存活分数的对数（log S/SO）与log(1 - M)之间应该存在线性关系，其中M是突变频率。对于低频情况，该关系呈现更简单的形式M = -m log S/SO。关于真核生物实验诱变的已发表文献证实了这些预期。当不同诱变剂在给定类型的细胞中诱导相同突变（或给定诱变剂在不同类型的细胞中诱导相同突变）时，观察到的斜率m的差异意味着突变和细胞失活并非仅由一种类型的DNA损伤引起。
