[二唑 -（N-水杨醛叉-L-α-丙氨酸根）-铜配合物的抗菌活性]

[Antimicrobial activity of diazole-(N-salicylidene-L-alpha- alaninato)-copper complexes].

作者信息

Blahová M, Sokolík J, Sedlácková S, Burianová E, Mlynarcík D

机构信息

Katedra chemickej teórie lieciv a Katedra biochémie a mikrobiológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.

出版信息

Cesk Farm. 1993 Jun;42(3):137-40.

PMID:8402967

Abstract

The antimicrobial activities of a group of copper(II) chelates with the composition [Cu(TSB)(L)] or [Cu(TSB)(L')]. (TSB = N-salicylidene-L-alpha-alaninate dianion, L = imidazole and its alkyl derivatives, L' = pyrazole and 3,5-dimethylpyrazole) were studied. Bis-diazole complexes with L' = pyrazole and 3,5-dimethylpyrazole were found to be the most active against S. aureus (MIC = 78 and 20 micrograms.cm-3), less effective against C. albicans (156 micrograms.cm-3), T. terrestre and M. gypseum (100 micrograms.cm-3). The observed biological properties of complexes are discussed in relation to their proposed structures.

摘要

研究了一组组成为[Cu(TSB)(L)]或[Cu(TSB)(L')]的铜（II）螯合物的抗菌活性。（TSB = N-水杨醛-L-α-丙氨酸二价阴离子，L = 咪唑及其烷基衍生物，L' = 吡唑和3,5-二甲基吡唑）。发现L'为吡唑和3,5-二甲基吡唑的双二唑配合物对金黄色葡萄球菌活性最高（MIC = 78和20微克·厘米-3），对白色念珠菌（156微克·厘米-3）、土曲霉和石膏样毛癣菌（100微克·厘米-3）效果较差。根据其推测结构讨论了配合物观察到的生物学性质。