Zhong S, Wyllie A H, Barnes D, Wolf C R, Spurr N K
Biomedical Research Centre, Ninewells Hospital, Dundee.
Carcinogenesis. 1993 Sep;14(9):1821-4. doi: 10.1093/carcin/14.9.1821.
Mammalian cytosolic glutathione S-transferases (GSTs; EC 2.5.1.18) form a supergene family consisting of four distinct families, named alpha, mu, pi and theta. In humans one member of the mu class gene family (GSTM1) has been shown to be polymorphic and is only expressed in 55-60% of individuals. Previous studies have shown a possible link with the null phenotype and susceptibility to cancer, in particular to lung cancer. In this study we genotyped individuals with breast, bladder and colorectal cancer. A total of 490 individuals with cancer were studied, and consisted of 97 bladder, 197 breast and 196 colorectal cancers. No significant differences were observed in the frequency of nulled individuals in bladder or breast cancer patients when compared with a control population of 225 individuals. However, a significant excess of nulled individuals were seen in colorectal cancer: 56.1% compared with the control group value of 41.8%. This was shown to be highly significant depending on the site of the tumours and > 70% of individuals with a tumour in the proximal colon were GSTM1 nulled. This is an approximately 2-fold increase in colon cancer risk in these individuals.
哺乳动物胞质谷胱甘肽S-转移酶（GSTs；EC 2.5.1.18）构成一个超基因家族，由四个不同的家族组成，分别命名为α、μ、π和θ。在人类中，μ类基因家族的一个成员（GSTM1）已被证明具有多态性，仅在55%至60%的个体中表达。先前的研究表明，它与无效表型以及癌症易感性，尤其是肺癌易感性之间可能存在联系。在本研究中，我们对患有乳腺癌、膀胱癌和结直肠癌的个体进行了基因分型。总共研究了490名癌症患者，其中包括97名膀胱癌患者、197名乳腺癌患者和196名结直肠癌患者。与225名个体的对照人群相比，在膀胱癌或乳腺癌患者中，无效个体的频率未观察到显著差异。然而，在结直肠癌患者中观察到无效个体显著过多：56.1%，而对照组的值为41.8%。结果显示，根据肿瘤部位的不同，这一差异具有高度显著性，并且近端结肠癌患者中>70%的个体GSTM1基因缺失。这些个体患结肠癌的风险增加了约2倍。
