通过聚合酶链反应分离和克隆人类慢肌肌钙蛋白（TNNT1）基因的基因组DNA片段。
Isolation and cloning by a polymerase chain reaction of a genomic DNA fragment of the human slow skeletal troponin (TNNT1) gene.
作者信息
Novelli G, Gennarelli M, Sangiuolo F, D'Agruma L, Lo Cicero S, Melchionda S, Dallapiccola B
机构信息
Chair of Human Genetics, Catholic University of Rome, Italy.
出版信息
Cell Biochem Funct. 1993 Sep;11(3):187-91. doi: 10.1002/cbf.290110306.
PMID:8403232
Abstract
The genomic 3' structure of the gene coding for the human slow skeletal troponin T (TNNT1) gene, is reported. An intron of 912 nucleotides containing an Alu-element has been identified and characterized. The complexity of the sequenced region suggests an alternative exon use. The present results may be valuable for further studies on the gene structure of TNNT1 and the related troponin gene family.
摘要
报道了编码人慢肌肌钙蛋白T（TNNT1）基因的基因组3'结构。已鉴定并表征了一个含有Alu元件的912个核苷酸的内含子。测序区域的复杂性表明存在外显子的选择性使用。目前的结果可能对进一步研究TNNT1的基因结构及相关肌钙蛋白基因家族具有重要价值。
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