系统性红斑狼疮患者单核细胞中吞噬作用引发的呼吸爆发。
Triggering of respiratory burst by phagocytosis in monocytes of patients with systemic lupus erythematosus.
作者信息
Gyimesi E, Kavai M, Kiss E, Csipö I, Szücs G, Szegedi G
机构信息
Third Department of Medicine, University Medical School of Debrecen, Hungary.
出版信息
Clin Exp Immunol. 1993 Oct;94(1):140-4. doi: 10.1111/j.1365-2249.1993.tb05991.x.
The triggering of the respiratory burst by phagocytosis via different receptors in monocytes of patients with systemic lupus erythematosus (SLE) was investigated. The superoxide anion synthesis was assayed by reduction of ferricytochrome C that was inhibited by superoxide dismutase. The mononuclear cell suspensions were triggered by IgG-coated latex, C3 complement fragment-coated and uncoated yeast (Saccharomyces cerevisiae). Superoxide generation induced by phagocytosis via Fc gamma R was decreased in monocytes of patients with SLE. On the other hand, MoAbs against Fc gamma RI, Fc gamma RII and especially CR3 could also induce superoxide anion synthesis. At the same time, superoxide generation induced by anti-CR3 could be inhibited with C3-coated yeast.
研究了系统性红斑狼疮（SLE）患者单核细胞中通过不同受体的吞噬作用引发呼吸爆发的情况。通过高铁细胞色素C的还原测定超氧阴离子合成，该还原反应受超氧化物歧化酶抑制。单核细胞悬液由IgG包被的乳胶、C3补体片段包被和未包被的酵母（酿酒酵母）触发。SLE患者单核细胞中通过FcγR的吞噬作用诱导的超氧生成减少。另一方面，针对FcγRI、FcγRII尤其是CR3的单克隆抗体也可诱导超氧阴离子合成。同时，抗CR3诱导的超氧生成可被C3包被的酵母抑制。
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